منابع مشابه
Circular RNAs in Cardiovascular Disease: An Overview
Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an increasing number of scientists have demonstrated that circRNAs may have played an essential role in...
متن کاملCircular RNAs in rat models of cardiovascular and renal diseases.
Circular RNAs (circRNAs) have emerged as an important new class of genomic regulatory molecules contributing to the development of various diseases, but their relevance to the development and progression of hypertension remains largely unknown. A major impediment to begin studying circRNAs in rat models of inherited hypertension is that the rat as a valuable model of human diseases lags far beh...
متن کاملCircular RNAs in Eukaryotic Cells.
Circular RNAs (circRNAs) are now recognized as large species of transcripts in eukaryotic cells. From model organisms such as C. elegans, Drosophila, mice to human beings, thousands of circRNAs formed from back-splicing of exons have been identified. The known complexity of transcriptome has been greatly expanded upon the discovery of these RNAs. Studies about the biogenesis and physiological f...
متن کاملBiogenesis of Circular RNAs
Circular RNAs are generated during splicing through various mechanisms. Ashwal-Fluss et al. demonstrate that exon circularization and linear splicing compete with each other in a tissue-specific fashion, and Zhang et al. show that exon circularization depends on flanking intronic complementary sequences. Both papers show that several types of circular RNA transcripts can be produced from a sing...
متن کاملThe expanding repertoire of circular RNAs.
I n recent years, reports suggesting a process of exon shuffling and the generation of circular RNAs have not gained wide support because they are inconsistent with the established dogma of linear exon splicing. This debate has now come full circle with evidence proving more definitively the existence of circular RNAs in two recent articles published in the 21 March issue of Nature. These artic...
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ژورنال
عنوان ژورنال: Non-coding RNA Research
سال: 2018
ISSN: 2468-0540
DOI: 10.1016/j.ncrna.2018.02.002